[2] The hospital is located on the campus of the University of Pennsylvania, along with several other related organizations including a medical school, a nursing school, veterinary and dental schools, research laboratories and outpatient facilities including the Abramson Cancer Center and the Roberts Proton Therapy Center.

Although it engages in many collaborative efforts with Penn Medicine, CHOP is not part of the University of Pennsylvania Health System.

[citation needed] The Chester County Hospital and Health System joined Penn Medicine in 2013.

[5] In 2020, the hospital accelerated the development of its new $1.5 billion "Pavilion" site in order to build additional capacity to combat the COVID-19 crisis.

The Hospitals of the University of Pennsylvania-Penn Presbyterian were nationally ranked for excellence in 12 specialties.