The Ruth and Raymond Perelman Center for Advanced Medicine is a specialized medical facility located at 34th Street and Civic Center Boulevard, on the former site of the Philadelphia Civic Center, on the campus of the Hospital of the University of Pennsylvania.

The $302-million project was designed by Rafael Viñoly Architects and completed in 2008.

It was the largest capital project ever undertaken by the University of Pennsylvania Health System, until the construction of The Pavilion.

[1] The center is home to Penn Medicine's Abramson Cancer Center, radiation oncology, cardiovascular medicine and an outpatient surgical pavilion.

[2] The proton therapy center will be used by both the Walter Reed Army Medical Center and the Children's Hospital of Philadelphia, as well as the Penn Medicine to treat cancer patients.