Hostomice (German: Hostomitz) is a market town in Teplice District in the Ústí nad Labem Region of the Czech Republic.

A notable feature of the market town's panorama is the hill Husův vrch at 266 m (873 ft) above sea level.

[3] The first written mention of Hostomice is from 1225, when the village was donated to the newly established monastery in Světec.

Coal was mined in the vicinity of Hostomice and a railway line was built, which led to an influx of population.

[4] The I/13 road (the section from Most to Teplice, part of the European route E442) passes through the market town.