House of Mystery is an American occult and horror-themed comic book anthology series, based on the series The House of Mystery that ran from 1951 to 1983.

Seven years later, in Texas, a former architecture student named Bethany "Fig" Keele flees her burning house, saving only a handful of sketches she once made of a house from her dreams.

Keele is pursued by a "Pair of the Conception", agents of an entity known as the "Omneity"; they are two people, a male and a female, always holding hands.

Everyone must pay for their drinks with stories and no one can leave without being picked up by the house's mysterious coachman.

None of the House's occupants are sure why some people might get to leave and others not, so each person's stay is, at least ostensibly, eternal until the coachman inexplicably turns up to take them away.