[1] Its county seat is Perry; the city of Warner Robins is substantially larger in both area and population.

[3] It was named after Georgia governor John Houstoun, with the spelling being a common 19th-century variation that later evolved to "Houston".

Flat Creek Public Fishing Area is in Houston County, south west of Perry.

[6] The county is located in the upper Atlantic coastal plain region of the state.

In the 2018 gubernatorial election, while she did not carry Houston County, Stacey Abrams improved on Democratic margins in the county, improving five percent compared to Hillary Clinton's 2016 presidential run and by four percent compared to Barack Obama's 2008 run.