The podcast is about Marlo Mack raising her 13-year-old transgender daughter.

[7] Mack is a single mom living in Seattle.

[8] The show has had Jazz Jennings as a guest.

[9] Marlo Mack wrote a piece in The New York Times about the podcast, which says that Marlo Mack is a pseudonym.

[2][14] Marlo Mack has adapted How to be a Girl into a memoir that is available as an audiobook.