Hrubá Vrbka (German: Gross Wrbka) is a municipality and village in Hodonín District in the South Moravian Region of the Czech Republic.

It has about 600 inhabitants.

Hrubá Vrbka, a part of traditional ethnographic region Horňácko, lies approximately 25 kilometres (16 mi) east of Hodonín, 73 km (45 mi) south-east of Brno, and 259 km (161 mi) south-east of Prague.

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