Vacenovice is a municipality and village in Hodonín District in the South Moravian Region of the Czech Republic.

The first written mention of Vacenovice is from 1228, when King Ottokar I donated the village to the monastery in Velehrad.

The only protected cultural monument in the municipality is a Baroque statue of St. John of Nepomuk, dating from the second half of the 18th century.

[5] The main landmark of Vacenovice is the Church of the Sacred Heart.

In the interior there is a painting of the Sacred Heart by Jano Köhler.