The Old Customs House of Humacao (Spanish: Antigua Aduana de Humacao) is a historic building located in Punta Santiago, in the municipality of Humacao, Puerto Rico.

The structure was designed in the Spanish Colonial style, architecturally and typologically and finished in 1872 by the Department of Public Works of the Spanish Government in Puerto Rico.

Until this time, the customs house was a temporary wooden building, so the need for a permanent structure made it possible that, in 1865, it was decided to construct the present building to serve as the new customs house at Punta Santiago.

It was added to the United States National Register of Historic Places on May 18, 1995,[3] and to the Puerto Rico Register of Historic Sites and Zones on May 16, 2001.

This article about a property in Puerto Rico on the National Register of Historic Places is a stub.