In 2007, Goh et al. constructed a disease-gene bipartite graph using information from OMIM database and termed human disease network.
[2] In 2009, Barrenas et al. derived complex disease-gene network using GWAs (Genome Wide Association studies).
[4] In 2011, Cusick et al. summarized studies on genotype-phenotype associations in cellular context.
[5] In 2014, Zhou, et al. built a symptom-based human disease network by mining biomedical literature database.
[6] A large-scale human disease network shows scale-free property.