Human umbilical vein endothelial cell

They are used as a laboratory model system for the study of the function and pathology of endothelial cells (e.g., angiogenesis).

[1] They are used due to their low cost, and simple techniques for isolating them from umbilical cords, which are normally resected after childbirth.

Like human umbilical artery endothelial cells they exhibit a cobblestone phenotype when lining vessel walls.

[3] Conversely, overexpression of SIRT1 in HUVECs has been shown to inhibit cellular senescence.

[4] The polyphenol quercetin has been found to be an effective senolytic for inducing the death of senescent HUVECs.