Humanity's Last Stand is a fictional radical anti-mutant fringe group appearing in American comic books published by Marvel Comics.
The group's first appearance was in Uncanny X-Men Annual 1995.
The humans use drugs and or technologically enhanced suits in order to mimic mutant powers.
They also attempted to murder humans who sympathized with mutants, which led them to battle the Punisher and his allies.
One of their major tasks was the attempted assassination Reverend William Connover.