Huntington Avenue is a thoroughfare in the city of Boston, Massachusetts, beginning at Copley Square and continuing west through the Back Bay, Fenway, Longwood, and Mission Hill neighborhoods.

The E branch of the MBTA Green Line roughly follows Huntington Avenue underground from Copley Square until it rises above ground at the Northeastern portal.

[citation needed] An existing system of horse-drawn streetcar lines was extended onto Huntington Avenue around 1883, running in a dedicated median from Francis Street to the Boston Public Library.

On February 16, 1941, the Tremont Street Subway (which in 1914 had already been extended for other lines running through Copley Square) opened a streetcar portal on Huntington Ave near Northeastern University.

A statue of Cy Young stands on the current day Northeastern campus to commemorate the location of the pitcher's mound of the Huntington Avenue Grounds ballpark.