The Infirmary was the result of the United Charities of Huntsville, a group dedicated to helping the sick and needy.

1916 – The city appeals to the State Health Department for help after typhoid fever devastates the community.

Property was donated by Harry Rhett, Sr. 1926 – A modern hospital, the first of its kind in the Tennessee Valley, is built.

1967 – The state's first, on-site employee child care center opens at Huntsville Hospital.

1973 – Huntsville Hospital is selected as the teaching facility for UAH's School of Primary Medical Care.

1981 – The region's first open-heart surgery is performed at Huntsville Hospital by Dr. Stancil Riley.

1982 – Huntsville Hospital reincorporated under the State Health Care Authority Act.

Huntsville Hospital completes construction of a two car overhead tram system connecting the main facilities on campus.

2005 – Construction begins on a new 84 bed patient room tower and an expanded Emergency Department.

2024 - Huntsville Hospital enters an agreement to purchase DeKalb Regional Medical Center and its related physicians clinics in Ft. Payne, Alabama.