The 21-story hotel was built in 1979 and is owned by Cambridge Landmark, a Miami-based private equity firm.

[5] In 2018 a Miami-based private equity firm (Cambridge Landmark) paid $37.3 million to purchase the hotel.

[9] On October 14, 1912, the Gilpatrick was the site of an assassination attempt on the former President of the United States Theodore Roosevelt.

[10][11] A plaque commemorating the assassination attempt was added to the front of the Gilpatrick Hotel by the United Spanish War Veterans of Milwaukee County in 1926.

[12] On June 30, 2024, Dvontaye L. Mitchell, a 43-year-old African-American man, died after being pinned to the ground by four security staff members at the hotel.