It is used in special applications for polyurethane, such as enamel coatings which are resistant to abrasion and degradation from ultraviolet light.

It is used as a reactive building block for the preparation of other chemical products such as isocyanate terminated prepolymers and other urethane polymers.

[4] The isocyanate groups can undergo addition reactions at room temperature with compounds which contain active hydrogens especially amines and polyols.

The polymers formed tend to have abrasion and hydrolysis resistance as well as retaining gloss and physical properties upon weathering.

[5][6] A prepolymer made from H12MDI and incorporating dimethylol propionic acid can also be converted to light stable polyurethane dispersions.