[2] Bleeding and thrombosis generally begin in adulthood with the average age at the time of presentation and diagnosis being 32 years.
Excessive bleeding following major or minor surgery, including dental extractions, occurs in both females and males with the disorder.
Thrombotic complications of the disorder are often (≈50%) recurrent and can involve central and peripheral arteries, deep and superficial veins.
[4][5] Congenital hypodysfibrinogenemia is inherited as an autosomal dominant disorder caused by at least 32 different types of single mutations.
Where available, specialized laboratories can conduct studies to define the exact gene mutation(s) and fibrinogen abnormalities underlying the disorder.
[2] Measures to prevent and/or treat complications of hypodysfibrinogenemia should be tailored to the personal and family history of the individual by a specialized center.
[2][4] In individuals with a personal or family history of thrombosis, should be considered for long-term anticoagulation drugs such as low molecular weight heparin, coumadin, or rivaroxaban.