[5] The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains.

Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots.

Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.

Increased and decreased levels of γA/γ' fibrinogen have been associated with coronary artery disease and deep vein thrombosis respectively.

In the lung parenchyma of smokers, upregulation of FGG transcript levels has been reported.