The episode features the death of established character Arthur Digby (Rob Ostlere), a CT2 doctor who had worked on the show's fictitious Keller and AAU wards.
Writers worked alongside a consultant oncologist for medical advice to provide an accurate depiction of terminal cancer.
Consultant general surgeon Ric Griffin (Hugh Quarshie) tries to make Dom realise that it is Arthur's choice.
Consultant cardiothoracic surgeon Jac Naylor (Rosie Marcel) sets CT1 doctor Zosia March (Camilla Arfwedson) a series of surgical tasks to prove her worth.
Zosia ex-boyfriend, Specialist registrar Oliver Valentine (James Anderson) and Staff nurse Cara Martinez (Niamh Walsh) apologise to her for sharing a kiss.
Cara gives Oliver a picture of his dead wife Tara Lo (Jing Lusi) and Zosia spots him with it.
Arthur goes to visit CEO Henrik Hanssen (Guy Henry) and he tells him that he has finally realised what he wants from life.
[2] The events of the episode could have been different as producer Simon Harper later gave Ostlere the chance to have his character leave the show alive.
[1] Storyliners had been liaising with a consultant oncologist named Bruce Sizer who gave advice on the medical condition featured in the episode.
[4] Writers structured the episode so it began "lovely and upbeat" until the closing scenes which contained Arthur's death.
[2] Former regular cast members Jimmy Akingbola and Lauren Drummond returned to filming especially for the episode, reprising their roles as Antoine Malick and Chantelle Lane respectively.
Drummond filmed scenes with other cast members, with her footage stylised as part of a dream sequence envisioned by Arthur.
[5] George Rainsford guest starred as Ethan Hardy, a character from Holby City's sister-show Casualty.
[2] After filming had wrapped for the episode Ostlere was supposed to give a farewell speech to the cast and crew but he was too upset.
[5] Advance spoilers only indicated that Arthur and Morven planned to leave Holby City to go travelling and that Zosia and Jac would feature in scenes on the show's Darwin ward.
[7] Sara Wallis from the Daily Mirror noted that hospital dramas can be emotional, but branded "I'll Walk You Home" a "particularly gritty and gruelling episode".
The scene involving Zosia and Jac breaking down in each other's arms "left viewers completely overcome with emotion".
"[15] Kayleigh Dray from Closer said the fact the episode featured the death of a "popular character" and made "tearjerking scenes".