The show's ensemble cast for series one consisted of Jimmy Akingbola, Joe Jacobs, David Sterne, Cal MacAninch, James Hillier, Kacey Ainsworth, Richard Harrington, Zöe Lucker, Chloe Howman, Kieran O'Brien, Tim Pigott-Smith and Elaine Glover.
Tony Jordan was recruited to write scripts for the show and work out "how storylines between the police station and the hospital could be intertwined.
"[6] The first series began filming at the end of January 2007,[7] commenced airing on 8 May 2007 at 8 pm, one week later than scheduled for unknown reasons,[8] and concluded on 26 June 2007.
[9] On 21 June 2007, it was announced that HolbyBlue would air a second series in 2008, this time for an extended run of twelve episodes.
[10] Filming recommenced in late 2007 in Surrey,[10] and the second series began airing on 20 March 2008, concluding on 5 June 2008.