[1] IMPDH motif RNAs are found in organisms classified within the genus Faecalibacterium.

IMPDH RNAs are often located upstream of genes that encode inosine monophosphate dehydrogenase.

Therefore, it is ambiguous whether IMPDH RNAs function as cis-regulatory elements or whether they operate in trans.

[2] Instead, it is suggested that it regulates transcription by "misincorporation" of inosine instead of one of the usual nucleotides (with ITP in place of GTP) into a string of RNA.

There may also be a role for the motif's binding to the bacterium's IMPDH protein.