2YSX363516331ENSG00000168918ENSG00000281614ENSMUSG00000026288Q92835Q9ES52NM_001017915NM_005541NM_001110192NM_001110193NM_010566NP_001017915NP_005532NP_001103662NP_001103663NP_034696Src homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) is an enzyme with phosphatase activity.

Its movement from the cytosol to the cytoplasmic membrane, where predominantly performs its function, is mediated by tyrosine phosphorylation of the intracellular chains of cell surface receptors that SHIP1 binds.

Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Highly conserved phosphatase domain is in central part of the protein.

This movement is mediated by binding its SH2 domain to the phosphorylated intracellular chains of cell surface receptors.

SHIP1 can also affect cell signaling pathways independently on its catalytic activity by serving as a bridge for other proteins thereby regulate protein-protein interactions.

In the case of autoinflammatory diseases, there is an attempt to increase SHIP1 catalytic activity by binding the small molecule to the C2 domain.