4RED, 4RER, 4REW, 5EZV5562105787ENSG00000132356ENSMUSG00000050697Q13131Q5EG47NM_006251NM_206907NM_001013367NM_001355640NP_001341964NP_001341965NP_001341966NP_001013385NP_0013425695'-AMP-activated protein kinase catalytic subunit alpha-1 is an enzyme that in humans is encoded by the PRKAA1 gene.

AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation.

It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.

Alternatively spliced transcript variants encoding distinct isoforms have been observed.

[6] A recent study proposes a role in the metastatic cascade and phenotype determination of pancreatic cancer.