Spire Studio is targeted to musicians, small bands, and home recordists, as well as the podcasting and meeting sectors.

Clients have included Sony, Adobe, Xbox, Harmonix,[37] Smule, Sonoma Wire Works, and most recently, Blue Microphones.

[39] iZotope has audio technology readily available in the form of VST, DirectX, AudioUnits, RTAS or AudioSuite plug-ins.

iZotope has developed plugins for use directly in Audiokinetic WWise for audio enhancement, voice effects occlusion and room modeling.

For middleware engines supporting XAudio and Multistream formats, iZotope has a collection of licensable DSP for use in music related games or karaoke.