From 2006 to 2016, he was director of the Computation Institute (CI), a joint project between the University of Chicago, and Argonne National Laboratory.
He is currently Director of the Data Science and Learning Division at Argonne National Laboratory, a unit established to tackle advanced scientific problems where data analysis and artificial intelligence can provide critical insights and accelerate discovery.
Methods and software developed under his leadership advanced discovery in areas as high energy physics, environmental science, and biomedicine.
For example, grid computing was credited by CERN director Rolf-Dieter Heuer as one of the elements essential for the 2012 discovery of the Higgs boson.
His Globus Toolkit project encouraged collaborative computing for engineering, business and other fields.