The Iglesia Parroquial de San Antonio de Padua (English: Parish Church of Saint Anthony of Padua) is a historic, Roman Catholic parish church in Guayama, Puerto Rico.

The original appearance of the building is unknown, but some of the eighteenth century walls may survive in the present structure.

The building was rebuilt twice in the nineteenth century and the present appearance dates from 1874.

It takes an overall Romanesque form, while the details exhibit the eclecticism that characterized much Puerto Rican architecture in the later 1800s.

This article about a property in Puerto Rico on the National Register of Historic Places is a stub.