In the 2016 mainline title Final Fantasy XV, Ignis and his companions oppose the rival empire of Niflheim and its efforts to dominate the world of Eos.

The character's story arc in the main narrative of XV culminates in him being permanently blinded, although he eventually acclimatizes to his condition and continues to be an active member of the player's party.

[7] The English localization of XV was led by Dan Inoue, who wrote Ignis to be a suave and logical character like a younger version of James Bond or Sherlock Holmes.

[11] A self-described fan of the character who has played Final Fantasy XV following its release and is familiar with its story, Mitsuda disclosed in an interview with VG247 that he may not have accepted Square Enix's invitation to score the DLC episode had it not featured Ignis.

Alongside Gladiolus Amicitia and Prompto, Ignis accompanies Noctis on a road journey to the city-state of Altissia, where he is set to marry Lady Lunafreya Nox Fleuret from the realm of Tenebrae.

Shortly after the party's arrival in Altissia, the city-state became the site of a massive battle involving an invading Niflheim force and one of the deities of Eos, Leviathan.

Ignis is permanently blinded in the aftermath of Altissia's destruction, which instigates a period of conflict and tension between as the other members of the retinue struggle to process their hardships and loss.

[14] In early 2016, action figures of Ignis alongside Noctis, Gladiolus and Prompto were produced by Play Arts Kai and distributed for sale by Square Enix on its online store to promote the then-upcoming release of Final Fantasy XV.

Samuel Roberts from PC Gamer chose Ignis as his favorite character from the Final Fantasy series, and credited the game's "more detailed interactions" with party companions in comparison to past titles as an important influence on his choice.

[30] In article published by Paste Magazine, Salvatore Pane described Ignis' role within the group as the "brains, the cook, the hipster who wears glasses not because he needs them but because they look cool".

[31] In an article for ComicsVerse, Peter Swann noted that Ignis Scientia is a character who subverts notions of gender stereotypes in popular media; while he is the group's strategist, he is also for all intents and purposes a mother figure who cooks, cares for and cleans up after Noctis.

Swann is particularly amused by the relationship dynamic between Ignis and Gladiolus where they bicker over how to deal with Noctis' habits as a picky eater, and compared them to a married couple.

[32] Ciann Chow from SBS Food said Ignis is a fan favorite and the "break-out meme star" of XV, highlighting in particular his repertoire of more than 100 recipes from the in-game menu, his distinct British accent, and his memorable catchphrase.

Chris Carter from Destructoid found Ignis to be less showy compared to his companions, but felt that the development team translated his resourceful quality well with the gameplay of the DLC.

Robert Ramsey from Push Square praised the DLC as the best in the character-driven Episode series, and said Ignis' "flashy, fast, and fluid fighting style" is likely the most enjoyable among Noctis' companions, which keeps enemy encounters engaging.

[35] Parrish concurred that "Ignis is by far the most fun to play", and said that she particularly enjoyed the smooth transition between different elemental powers and their associated mechanics when dealing with enemy units during intense combat sequences.

[22][40] Kyle Bradford from GameSpew said he was devastated by Ignis' initial struggle with his blindness and his insistence to press on alongside his companions in spite of his difficult circumstances.

[41] Pane highlighted the aftermath of Ignis' permanent disability and the rising tensions between members of the group as one of the best sequences he has ever experienced in a videogame, as it accurately portrays how teenage boys cope with grief in his view.