The Iguape-Cananéia-Paranaguá estuary lagoon complex (Portuguese: Complexo Estuarino Lagunar de Iguape-Cananéia-Paranaguá) is a stretch of interconnected coastal estuaries and lagoons that extends southwest from Iguape in the south of São Paulo past Cananéia, São Paulo to Paranaguá, Paraná.

Locally endangered species include great horned owl (Bubo virginianus), tufted capuchin (Sapajus apella), collared peccary (Pecari tajacu), white-lipped peccary (Tayassu pecari), crab-eating raccoon (Procyon cancrivorus) and South American tapir (Tapirus terrestris).

[2] The estuary-lagoon complex, and the Vale do Ribeira as a whole, have a coordinated approach to environmental management, with a number of conservation units of different types.

[6] The main environmental threats come from inefficient handling of chemical products in the port of Paranaguá, tourism-related real estate speculation in the beach areas, dumping of toxic agricultural waste and heavy metals into the Ribeira de Iguape River, which flows into the estuary, and lack of adequate sewage infrastructure.

[2] Implementation in 2002 of the 1,175 hectares (2,900 acres) Mandira Extractive Reserve, whose inhabitants are mainly involved in collecting mangrove oysters (Crassostrea brasiliana), was a positive example of sustainable development.

With recognition and help in marketing, the people of the reserve became proud of their environmental conservation work and the quality of their products, and are seen as leaders in the region.