Illinois Route 95 is a minor east–west state route in west central Illinois.

It runs from Illinois Route 41 just west of New Philadelphia east to Illinois Route 97 just south of Cuba.

[1] Illinois 95 makes up part of direct highway between Macomb and Canton without touching either.

It is an undivided, two-lane surface state route for its entire length.

In March 1937 this was changed to its modern alignment.