It is housed in the former Wilson Federal Building which served as a post office with a federal courthouse of the United States District Court for the Eastern District of North Carolina from its construction in 1928.

2009 North Carolina Museum of The Coastal Plain opens on the third floor of Imagination Station.

2013 Nancy Van Dolsen becomes the museums seventh Executive Director.

The museum also offers outreach programs with their "Science & History on Wheels" (SHOW) which brings science demonstrations and history programs to classrooms and organizations across eastern North Carolina.

In the early 2000s, a fire at the building prompted a move to a smaller temporary location four blocks north.