The Immanuel Missionary Church was born out of a schism with the Pilgrim Holiness Church under the leadership of Ralph Goodrich Finch and D.W. Reynolds due to differences in the interpretation of the Methodist doctrine of entire sanctification; the connexion that became the Immanuel Missionary Church laid heavy emphasis on the death route to entire sanctification, in which "The body of sin must be destroyed for the second work of grace to be true" (cf.

[5] The choir of God's Bible School and College is noted to tour at Immanuel Missionary Church congregations.

[3] The connexion's Singing Hills Camp Meeting occurred annually in Shoals, Indiana, and since 2023, now takes place at Wesleyan Holiness Campground in Springfield, Illinois.

[3] The Immanuel Missionary Church has congregations in Indiana, Florida, Missouri, Oklahoma, Colorado, among other parts of the world.

[3][6] With respect to ecumenism, some members of the Immanuel Missionary Church participate in the Interchurch Holiness Convention.