Immanuel Ngatjizeko was born in Otjohorongo, a village near Omaruru in Namibia's central Erongo Region.

[1] After his return to South West Africa he worked at the Council of Churches in Namibia until 1994, heading its Finance Department.

He then started working full time for SWAPO, first as Managing Director of its investment company Zebra Holdings, and from 1997 as party Secretary for Finance.

Under President Hage Geingob, Ngatjizeko moved back to the post of Minister of Industrialisation, Trade and SME Development in March 2015.

[4] In a Cabinet reshuffle in February 2018 he became Minister of Presidential Affairs[5] but resigned shortly thereafter and retired due to health issues.