Khan graduated from Mithibai College with a degree in commerce.
Khan's first film as an actor was 1991's Inteha Pyar Ki starring Rishi Kapoor and Ruksar.
He then worked in movies such as Sangam Hoke Rahega in 1994, Karamveer, Mohabbaton ka Safar in 1995, Kismat, Big Brother, Heroine, Sooryavansham, Khiladiyon Ka Khiladi, Hawa, Dil Toh Baccha Hai Ji and 23rd March 1931: Shaheed.
This was followed by Dastaan, Parampara, Ajnabi, Nagin, Chandni, Aashirwad, Astitwa, Ammaji Ki Gali, Jiny and Jeeju, and I Love My India.
Imran Khan Productions has produced television films and TV serials such as Haya for Ary digital, and Nakhuda for Zee.