In June 1820 Indian sailed from Valparaiso for the newly discovered South Shetland Islands and their sealing grounds.

[a] Indian arrived back at Plymouth on 27 May 1821, having left the New South Shetlands on 13 March and Pernambuco on 21 April.

[4] She brought with her Robert Fildes and some of his crew from Cora, which had wrecked at Desolation Island, as well as eight men from another damaged sealer.

[6] Lloyd's List reported on 5 October that Indian had been wrecked at 43°N 64°W / 43°N 64°W / 43; -64 while on her way from Saint John, New Brunswick, to Belfast.

On 19 October Lloyd's List reported that Mayflower had seen an abandoned vessel at 43°N 65°W / 43°N 65°W / 43; -65 that was believed to have been Indian.