Indian Creek is a tributary of the Guyandotte River, 19.7 miles (31.7 km) long,[3] in southern West Virginia in the United States.

Indian Creek's entire course and drainage area are in southern Wyoming County.

It rises in southeastern Wyoming County, approximately 5 miles (8.0 km) south of New Richmond, and flows generally northwestward, through the unincorporated communities of Wolf Pen, Fanny, and Fanrock.

It flows into the Guyandotte River from the south, approximately 0.3 miles (0.48 km) east of Baileysville.

[5] According to the West Virginia Department of Environmental Protection, approximately 97.7% of the Indian Creek watershed is forested, mostly deciduous.