After barely escaping with his life from an archaeological dig in Tikal, Guatemala, Dr. Henry Jones Jr. makes his way back to New York.

There he learns of the recent discovery of the mysterious writings of a missing British explorer, Colonel Percy Fawcett.

Though Colonel Fawcett himself still remains missing, his rediscovered work tells a story that could drastically change history and challenge several firmly held scientific beliefs.

Within those pages, an incredible picture begins to take shape of a long lost city in the jungles of Brazil and the apparently true legend of a red-headed race, possibly descended from ancient Celtic Druids.

Fascinated by such a prospect, and with the lovely Deidre Campbell at his side, Indiana Jones sets out for the Amazon.