Its southern terminus is at State Road 135 near the town of Mauckport, which is on the Ohio River.

From there, the highway runs roughly northeast for a distance of about 30 miles (48 km) and ends where it meets State Road 62, east of the town of Lanesville.

The northern portion is a north–south road in Bartholomew and Jackson counties.

Its southern terminus is at State Road 250 in the small town of Dudleytown a few miles south of Seymour; the highway runs north through Seymour to Columbus, a distance of about 26 miles (42 km), and ends where it meets Indiana State Road 46.

In the 1970s the northern section of SR 11 was numbered U.S. Route 31 Alternate.