Within Evansville, SR 62 forms part of the Lloyd Expressway, a divided expressway-grade highway that serves as a major east–west traffic artery through the city.

For much of its trip through Spencer, Perry, Crawford, Harrison, and western Floyd counties, it is narrow, winding, and hilly.

[dubious – discuss] It is named in honor of former Mayor Russell G. Lloyd, Sr. who was assassinated after leaving office in 1980.

[citation needed] The road was built in various stages and officially opened on July 19, 1988.

The west section of the expressway was completed in the 1950s with plans to continue it east at a later date as funding became available.