U.S. Route 50 (US 50) is a part of the United States Numbered Highway System that runs from West Sacramento, California, to Ocean City, Maryland.

US 50 enters Indiana over the Wabash River and a CSX railroad track as a four-lane, divided highway passing through rural farmland north of Vincennes.

The two routes head east towards Washington, as a four-lane divided highway passing through rural farmland.

The concurrency heads north through the downtown area of Loogootee as a two-lane highway, passing commercial and residential properties.

The two routes head north, turning northeast crossing the east folk of the White River.

The concurrency heads towards downtown Bedford, passing through commercial and residential properties, as a four-lane highway with a center turn lane.

US 50 enters Seymour and becomes a four-lane undivided highway, passing through commercial and residential properties, parallel to a CSX Railroad track.

The route leaves downtown Seymour heading east passing through commercial properties and having an interchange with I–65 (coincidentally also numbered Exit 50).

The road leaves the North Vernon area heading northeast towards Versailles, passing through farmland.

[2][3][4] The route heads south east toward Dillsboro, passing through an intersection with State Road 101.

The route leaves Lawrenceburg heading northeast as a four-lane undivided highway passing through woodland.

[5] The NHS is a network of highways that are identified as being most important for the economy, mobility and defense of the nation.

This measurement is a calculation of the traffic level along a segment of roadway for any average day of the year.

[7] US 50 was first signed 1917 as Main to Market Highway number Five, from Illinois state line to Mitchell.