The southern terminus of State Road 111 is at a dead end on the shores of the Ohio River, near the small community of New Boston.

From there, it runs to the north and east, closely following the course of the river for about 13 miles (21 km), at which point it intersects with the east–west State Road 211.

It continues north, entering downtown New Albany.

From there, it turns to meet at its current northern terminus at the intersection of Main Street and State Street.

When U.S. Route 33 (US 33) was commissioned in Indiana, SR 33 was decommissioned.