State Road 245 begins at State Road 70 east of Newtonville and runs north.

Passing through Santa Claus, it is concurrent with State Road 162 and serves the Holiday World & Splashin' Safari theme park.

Past the park, the concurrent routes run along Christmas Boulevard, while the northern stretch of State Road 245 that leads northwest out of town toward Dale is called Holiday Boulevard.

This segment of highway was decommissioned by the state and is now a county road.

The entire route is in Spencer County.