The southern terminus of State Road 29 is at U.S. Route 421 and State Road 28 just south of the small town of Boyleston.

Going north, it passes through Michigantown in Clinton County, then along the eastern border of Carroll County where it passes through Burlington.

At one time, State Road 29 was much longer, going from Madison in the south to Michigan City in the north; when US 421 was commissioned, it took over much of the route.

The route from Logansport to Michigan city followed the current US 35.

SR 29's northern terminus was truncated to Logansport by 1955 in favor of US 35.