Running for about 23 miles (37 km) in a general east–west direction, connecting Osgood, Milan, and Aurora.

In Pierceville the road parallels a CSX Transportation rail track, passing a few residential properties.

While in rural Dearborn County the road passes near Sparta, Mount Sinai, and just north of Wilmington.

East of Wilmington SR 350 passes South Dearborn High School, before entering Aurora.

[3][4] SR 350 had its beginning in 1931 when it was designated, by Indiana State Highway Commission, from Milan to Aurora.