It is broken in Franklin from Indiana State Road 144 and Interstate 65.

From Martinsville, its western terminus, at I-69, SR 44 heads east toward Franklin.

Upon entering Franklin SR 44 ends at the intersection with State Road 144.

[3] (The route continues east as Jefferson St. and crosses US 31 and onto Forsythe and King Streets to Interstate 65.)

In Rushville SR 44 has a short concurrency with U.S. Route 52 and an intersection with State Road 3.