In Mitchell, SR 60 is concurrent with State Road 37.

After Mitchell SR 60 heads southeast toward Salem, passing through Campbellsburg.

Southeast from downtown Salem SR 60 has an intersection with Indiana State Road 160.

SR 60 leaves Salem heading south-southeast towards Sellersburg, passing through New Pekin, Borden, and Bennettsville.

In Sellersburg SR 60 passes over Interstate 65 (I-65), followed by an intersection at U.S. Route 31.