The western terminus of SR 32 is at the Illinois state line, southeast of Danville, Illinois, where the state highway becomes a county road.

Between the Illinois state line and Crawfordsville, the highway runs somewhat parallel to Interstate 74.

East of Crawfordsville, the highway is a popular alternate route for traffic from parts north and northeast of Indianapolis heading for westbound I-74.

Between I-65 and Fishersburg, Indiana, SR 32 travels through Boone, Hamilton, and Madison counties.

Continuing east from Fishersburg, SR 32 serves the towns of Lapel, Anderson, Muncie, Winchester, and Union City.