The Greyhounds compete in NCAA Division II as members of the Great Lakes Valley Conference (GLVC).

In recent years, the Greyhounds have emerged as one of the top all-around athletics programs in Division II.

Since 2011–12, Indianapolis has placed in the top ten of the Division II Learfield Directors' Cup standings ten times, and has won every GLVC All-Sports Trophy.

UIndy added two more women's sports, bowling and triathlon, in fall 2024.

Varsity sports records date from 1922, with the hiring of the first full-time coach and athletic director.