[3][4] In 2013, Indigo was founded as Symbiota by Noubar Afeyan and Geoffrey von Maltzahn through Flagship Pioneering partners David Berry and Ignacio Martinez,[5] led by former CEO David Perry, as a company developing environmentally friendly microbes that could be applied to seeds to produce better yielding crops.

[18] By 2018 the company has also launched similar seed treatments to improve drought resistance in wheat, corn, soybeans, rice, and barley.

[2] In 2017, the first year this model was implemented, Indigo contracted approximately half a million acres in cotton, wheat, corn, soy, and rice.

[21] In Europe, Indigo has created a Carbon credits program in Germany, working with German company Beiselen.

[23] Indigo worked with the Climate Action Reserve and Verra to publish protocols, creating guidance for the program.

[27] In February 2021, the VF Corporation partnered with Indigo to source regenerative cotton for use in The North Face products.