Infiniti presented a preliminary concept for the EX at the 2007 New York Auto Show,[2] notable for its surround-view camera (marketed as Around View Monitor), lane departure system, V6 engine, 5-speed automatic transmission, all-wheel-drive, double-arch grille, large L-shaped headlights with adaptive front lighting system (AFS), integrated fog lights, LED taillights and an "arch" profile design.

Infiniti presented the EX35 production model at the 2007 Pebble Beach Concours d'Elegance,[3] followed by Jamsil Olympic Stadium in Seoul.

Models sold in Canada, Europe include ATTESA E-TS AWD as standard.

The cameras are located at the front, back and sides of the vehicle and feed images to an image processing unit; those individual inputs are analyzed, synthesized to offer a synthetic, but positionally accurate, somewhat lifelike top-down view of the car and its surroundings.

The process, which takes anywhere from one day to one week (depending on the surrounding temperature and the depth of the scratch), is accomplished through the use of an elastic resin.

It is combined with a conventional clearcoat to increase the paint's flexibility and strength by raising the resin density.

[10] This utilizes the electronic stability control system to help assist the driver in maintaining lane position by applying gentle brake pressure on each wheel individually to generate intended movement.

It sounds an alert and nudges the vehicle in the correct direction when lane departure is detected.

Early models include VQ37VHR 3.7-liter V6 (326PS) engine with all wheel drive, 7-speed automatic transmission with manual shift mode, DS mode with Downshift Rev Matching (DRM), and Adaptive Shift Control.

[15] Production of the Chinese models of QX50L at Xiangyang plant in Hubei Province was set to begin in 2014.

[21][22] Changes include overall length increased by 80 millimeters (3.1 inches), a redesigned grille and front bumper assembly that incorporate LED daylight running lights, optional automatically opened and closed tailgate hatch, optional full panoramic glass roof.

[25] The production version of the second-generation QX50 was presented at the 2017 LA Auto Show as a 2019 model with a turbocharged 2.0 L KR20DDET gasoline engine using Nissan's VC-T variable compression ratio system.

Production of the QX50 began in November 2017 at COMPAS, a Nissan and Daimler AG's joint plant in Aguascalientes, Mexico.

Introduced in the first quarter of 2021 for the 2022 model year, the QX55 is a "coupé SUV" version of the QX50 with a more sloped roof design.