It comes in one trim level, with only key options such as: DVD entertainment system, 4WD/2WD, and a bench instead of captain chairs as the second row.

[5][6] Introduced at the 2007 North American International Auto Show in January 2007, the facelifted model went on sale in April 2007.

[citation needed] By 2007, a styling proposal by Shinya Momokawa and Akihiro Sugita was approved by the board and frozen for production.

Most of the frame's body mass is made from high-tensile steel, but the QX manages to be more rugged with its body-on-frame concept.

[citation needed] The QX56 features a new 5.6-liter VK56VD V8 engine with direct injection and VVEL variable valve timing, also found in the Patrol, which is rated at 400 hp (298 kW) and 413 lb⋅ft (560 N⋅m) of torque.

The QX also features the updated Infiniti hard drive based navigation system with an eight-inch VGA display.

[10] The 2015 model year QX80 arrived at the New York International Auto Show with a mid-generational refresh, receiving new headlights and taillights with new front and rear fascias, restyled bi-xenon HID projector headlamps with LED daytime running lights, front LED turn signals (located on front bumper with new LED fog lights), new wheel designs (including a new 22-inch forged-aluminum version), three new exterior colors, and a number of interior refinements for the 2015 model year.

[citation needed] As of 2017, the Infiniti QX80 is available in the United States (including all US territories), Canada, Mexico, China (including Macau and Hong Kong), the GCC markets, Russia, Ukraine, Azerbaijan, South Korea, Dominican Republic, Guam, Panama, Australia, Malaysia, Singapore and Vietnam.

In 2021 for the 2022 model year, Infiniti updated the QX80[15] featuring an all-new infotainment system and a 12.3 touchscreen display, replacing the dated two-screen setup.

[16] The QX80 also features new climate control switches, wireless charging, Android Auto and Apple CarPlay with navigation standard is included with the QX80 and Infiniti's InTouch connected services.

[21] The interior has two 14.3 in (36 cm) displays for the driver's instrument cluster and the main Infiniti InTouch® infotainment system with Google built-in.

Below the infotainment system, is an additional 9 in (23 cm) touchscreen display (that uses haptic feedback) for the climate controls, front seat cooling and heating functions and the drive mode selection.

Other interior features are a 64-color Personalized Ambient Lighting with light pipes on the dashboard and door panels, Biometric Cooling for the second-row seats, colored heads-up display, heated third row seats, Journey Diary functionality which can save photo and video footage from the front and in-car cameras, and a Klipsch audio system.

[21] All QX80 models are powered by a 3.5-liter twin-turbocharged V6 gasoline engine producing 450 hp (336 kW) and 516 lb⋅ft (700 N⋅m) of torque paired a 9-speed automatic transmission, with the option between RWD and an Infiniti All-mode 4WD system.